Happenings | Y Lab

2021

Nov, 2021

Yang lab has a group dinner to celebrate the achievements of our postdocs, graduate students, and undergraduate students.

Nov, 2021

Congrats to Muriel for winning the prestigious Jenkins-Knevel Award for Excellence in Research from Purdue College of Pharmacy and giving a fanatics talk about her thesis work!

Nov, 2021

Yang met the CEO and CTO of Axion Biosystems and strengthened our relationship with our industry partners.

Nov, 2021

Yang visited Emory University and gave a seminar talk. Photo with a good friend Asheebo.

Oct, 2021

Yang visited Cincinnati Children's Hospital/ University of Cincinnati and gave a seminar talk.

Aug, 2021

Yang lab attended PULSe graduate students recruitment poster event. Looking for multiple PhD students to join the lab!

Aug, 2021

Really privileged to see this insightful spotlight preview by Dr. Leonard Kaczmarek discussing Dr. Bender and our recent back-to-back publications, published in a prestigious review journal "Trends in Neurosciences"! Being previewed is a big honor for any papers and we are humbled to receive this recognization. Feeling unreal but super excited that our works may redefine Action Potential 101!

Aug, 2021

Textbook dogma suggests that inadequacy of sodium channels results in impaired neuronal excitability. Jingliang's potential paradigm-shifting work, just published in Cell Reports, however, shows that severe deficiency in sodium channel Nav1.2 leads to unexpected hyperexcitability in neurons. Our paper is a back-to-back publication with a paper from Dr. Kevin Bender at UCSF, illustrating the beauty of open science. Big Congrats to Jingliang and the team!

July, 2021

Very humbled to receive our 2nd 5-year NIH R01 to study voltage-gated sodium channel Nav1.2 related neuronal hyperexcitability and seizures. It was wonderful to see the 2nd one coming during the Independence Day weekend, which was symbolic, certainly giving us huge independence to pursue our research goals! Thanks to all our lab members who made this possible. Special shout out to Jingliang for collecting exciting but "strange" results, which was the basis of this Award. The "strange data" eventually turned out to be paradigm-shifting and allowed us to challenge the current dogma!

July, 2021

Our collaborative project with pharmaceutical company Eli Lilly was published and featured on the cover of Pharmaceutical Research, an official journal of the American Association of Pharmaceutical Scientists. We helped to develop an in vitro sensory neuron-based assays to understand the nociceptive potential of pharmaceutical buffer systems used for injectable biologics. A well-tolerated buffer system is essential for drug formulation to develop successful medications to treat many diseases including cancers. Congrats to Muriel and Jeff for leading the effort and getting the work done!

June, 2021

Yang served as an ad hoc reviewer of the NIH Clinical Neuroplasticity and Neurotransmitters (CNNT) study section.

April, 2021

Our lab's first 5-year R01 to study Scn2a deficiency related to autism was funded by NINDS! It is truly a group effect from all lab members, but special thanks go to Jingliang and Muriel!

April, 2021

Our first paper of the unique gene trap mouse model of Scn2a deficiency was published and featured on the cover of Genes, Brain and Behaviors, the official journal of the International Behavioural and Neural Genetics Society. Many exciting studies to follow using this important mouse model. Check out Muriel's paper!

46C 2021 Genes Brain Behav Cover image g

Jan, 2021

Excited to receive funding from PIDD-PIIN Alzheimer's disease and other dementias program to generate human microglia from induced pluripotent stem cells to study the interaction between microglia and neurons! Thanks to Jeff and Maria for laying the groundwork for this study!

2020

Oct, 2020

We are grateful to receive the 2020 Action Potential Grant from the FamilieSCN2A Foundation to advance gene therapy of SCN2A related disorders! Way to go Muriel!