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(papers in which Dr. Yang is a leading corresponding author are highlighted in red, and Yang lab members are highlighted in red. Equal contributions are indicated with "&", and corresponding authors are indicated with "*"). 


Que Z&, Olivero-Acosta M&, Chen I, Zhang J, Wettschurack K, Wu J, Xiao T, Otterbacher CM, Wang M, Harlow H, Cui N, Chen X, Deming B, Halurkar M, Zhao Y, Rochet JC, Xu R, Brewster A, Wu LJ, Yuan C, Skarnes WC, Yang Y*. Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation, in revision with Journal of Neuroscience, BioRxiv



Wu J&, Zhang J&, Chen X&, Que Z, Wettschurack K, Deming B, Ascosta M, 2024 Mar 18. doi: 10.1038/s41380-024-02518-4Cui N, Eaton M, Zhao Y, Halurkar M, Purba M, Chen I, Xiao T, Suzuki M, Yuan C, Xu R, Koss W, Du D, Chen F, Wu LJ, Yang Y*. Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids, Molecular Psychiatry, 2024 Mar 18. doi: 10.1038/s41380-024-02518-4; Research Square preprint.

News coverage: Previewed in the Transmitter/Spectrum | Autism Research News: Microglial overreaction to atypical neurons may drive autism: In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.

Yuan T, Wang Y, Jing Y, Xu S, Zhang H, Chen Q, Li N, Ma X, Song H, Peng C, Yang H, Geng Z, Dong J, Duan G, Sun Q, Yang Y, Yang F, Huang Z. Coupling of Slack and Nav1.6 sensitizes Slack to quinidine blockade and guides antiseizure strategy development. eLife. 2024 Jan 30 version of record



Xie J, Wu S, Szadowski H, Min S, Yang Y, Bowman AB, Rochet JC, Freeman JL, Yuan C. Developmental Pb exposure increases AD risk via altered intracellular Ca2+ homeostasis in hiPSC-derived cortical neurons. Journal of Biological Chemistry. 2023 July 7. DOI:

Xie J, Herr S, Ma D, Wu S, Zhao H, Sun S, Ma Z, Chan MY, Li K, Yang Y, Huang F, Shi R, Yuan C. Acute transcriptomic and epigenetic alterations at T12 after rat T10 spinal cord contusive injury. Molecular Neurobiology. 2023 February 08


Ma Z, Eaton M, Liu Y, Zhang J, Chen X, Tu X, Shi Y, Que Z, Wettschurack K, Zhang Z, Shi Y, Chen Y, Kimbrough A, Lanman NA, Schust L, Huang Z*, Yang Y*. Deficiency of autism-related Scn2a gene in mice disrupts sleep patterns and circadian rhythms, Neurobiology of Disease. 2022 March14; 168:105690.


Que Z&, Olivero-Acosta MI&, Zhang J, Eaton M, Tukker AM, Chen X, Xiao T, Wu J, Xie J, Wettschurack K, Yunis L, Shafer MJ, Schaber JA, Rochet JC, Bowman AB, Yuan C, Huang Z, Hu CD, Trader DJ, Skarnes WC, Yang Y*. Hyperexcitability and pharmacological responsiveness of cortical neurons derived from human iPSCs carrying epilepsy-associated sodium channel Nav1.2-L1342P genetic variant. Journal of Neuroscience, an official journal of the Society for Neuroscience. 2021 December 8; 41(49): 10194-10208.

Featured on the Cover, and previewed in "This Week in The Journal"

Zhang J&, Chen X&, Eaton M, Wu J, Ma Z, Lai S, Park A, Ahmad TS, Que Z, Lee JH, Xiao T, Li Y, Wang Y, Olivero-Acosta MI, Schaber JA, Jayant K, Yuan C, Huang Z, Lanman NA, Skarnes WC, Yang Y*. Severe deficiency of the voltage-gated sodium channel Nav1.2 elevates neuronal excitability in adult mice. Cell Reports. 2021 AUGUST 03, VOLUME 36, ISSUE 5, 109495

Spotlight preview in Trends in Neurosciences -- The NaVy paradox: reducing sodium currents increases excitability.

Eaton M, Que Z, Zhang J, Beck K, Shi R, McDermott J, Ladisch M*, Yang Y*. Multi-electrode array of sensory neurons as an in vitro platform to identify the nociceptive response to pharmaceutical buffer systems of injectable biologics. Pharmaceutical Research, an official journal of the American Association of Pharmaceutical Scientists. 2021 Jul;38(7):1179-86 Featured on the Cover.

Eaton M, Zhang J, Ma Z, Park AC, Lietzke E, Romero CM, Liu Y, Coleman ER, Chen X, Xiao T, Que Z, Lai S, Wu J, Lee JH, Palant S, Nguyen HP, Huang Z, Skarnes WC, Koss WA, Yang Y*. Generation and basic characterization of a gene-trap knockout mouse model of Scn2a with a substantial reduction of voltage-gated sodium channel Nav1.2 expressionGenes, Brain and Behavior, an official journal of the International Behavioural and Neural Genetics Society. 2021 April; 20(4):e12725 Featured on the Cover.

Zhang J&, Zhang C&, Chen X, Wang B, Ma W, Yang Y, Zheng R and Huang Z. PKA-RIIβ autophosphorylation modulates PKA activity and seizure phenotypes in mice. Communications Biology. 2021 March 1;4(1):263 (&, Equal contribution)

Xenakis MN, Kapetis D, Yang Y, Gerrits MM, Heijman J, Waxman SG, Lauria G, Faber CG, Westra RL, Lindsey PJ, Smeets HJ. Hydropathicity-based prediction of pain-causing NaV1.7 variants. BMC Bioinformatics. 2021 Apr 23;22(1):212

Xenakis MN, Kapetis D, Yang Y, Heijman J, Waxman SG, Lauria G, Faber CG, Smeets HJ, Lindsey PJ, Westra RL. Non-extensitivity and criticality of atomic hydropathicity around a voltage-gated sodium channel's pore: a modeling study. Journal of Biological Physics. 2021 Mar;47(1):61-77


Verma P&, Eaton M&, Kienle A, Flockerzi D, Yang Y*, Ramkrishna D*. Examining sodium and potassium channel conductances involved in hyperexcitability of chemotherapy-induced peripheral neuropathy: A mathematical and cell culture-based studyFrontiers in Computational Neuroscience. 2020 Oct 15;14:564980

Xenakis MN, Kapetis D, Yang Y, Heijman J, Waxman SG, Lauria G, Faber CG, Smeets HJ, Westra RL, Lindsey PJ. Cumulative hydropathic topology of a voltage-gated sodium channel at atomic resolution. Proteins. 2020 Oct;88(10):1319-1328

Chen X, Zhang J, Song Y, Yang P, Yang Y, Huang Z, Wang K. Deficiency of anti-inflammatory cytokine IL-4 leads to neural hyperexcitability and aggravates cerebral ischemia-reperfusion injuryActa Pharmaceutica Sinica B. 2020 Sep;10(9):1634-1645

Kong W, Tu X, Huang W, Yang Y, Xie Z, Huang Z. Prediction and Optimization of Nav1.7 Sodium Channel Inhibitors Based on Machine Learning and Simulated Annealing. Journal of Chemical Information and Modeling. 2020 Jun 22;60(6):2739-2753

Liu Y, Tang Y, Yang J, Du D, Yang Y, Chen F. Deletion of Kv10.2 causes abnormal dendritic arborization and epilepsy susceptibility. Neurochemical Research. 2020 Dec; 45(12):2949-58 


Jin X, Chen Q, Song Y, Zheng J, Xiao K, Shao S, Fu Z, Yi M, Yang Y, Huang Z. Dopamine D2 receptors regulate the action potential threshold by modulating T-type calcium channels in stellate cells of the medial entorhinal cortex. Journal of Physiology 2019 Jul;597(13):3363-3387 

Mis MA&, Yang Y&, Tanaka BS, Gomis-Perez C, Liu S, Dib-Hajj F, Adi T, Garcia-Milian R, Schulman BR, Dib-Hajj SD, Waxman SG. Resilience to Pain: A Peripheral Component Identified Using Induced Pluripotent Stem Cells and Dynamic ClampJournal of Neuroscience 2019, 39(3):382-392 (&, equal contribution) F1000 Faculty Opinions; Pain Research Forum news: Pain-in-a-Dish Expands the Nav1.7 Research Menu


Mis MA, Rogers MF, Jeffries AR, Wilbrey AL, Chen L, Yang Y, Dib-Hajj S, Waxman SG, Stevens EB, Randall AD. Differential aging-related changes in neurophysiology and gene expression in IB4-positive and IB4-negative nociceptive neurons. Aging Cell 2018, e12795

Yang Y, Mis MA, Estacion M, Dib-Hajj SD, Waxman SG. Nav1.7 as a pharmacogenomics target for pain: Moving towards precision medicine. Trends in Pharmacological Sciences 2018, 39(3):258-275

Yang Y, Adi T, Effraim P, Chen L, Dib-Hajj SD, Waxman SG. Reverse pharmacogenomics: carbamazepine normalizes activation and attenuates thermal-induced hyperexcitability of sensory neurons due to Nav1.7 mutation I234T. British Journal of Pharmacology 2018, 175:2261-71


Kapetis D, Sassone J, Yang Y, Galbardi B, Xenakis MN, Westra RL, Szklarczyk R, Lindsey P, Faber CG, Gerrits M, Merkies IS, Dib-Hajj SD, Mantegazza M, Waxman SG, Lauria G. Network topology of Nav1.7 mutations in sodium channel-related painful disorders. BMC Systems Biology 2017, 11:28


Han C, Yang Y, Te Morsche RH, Drenth JP, Politei JM, Waxman SG, Dib-Hajj SD. Familial gain-of-function Nav1.9 mutation in a painful channelopathy. Journal of Neurology, Neurosurgery & Psychiatry 2017, 88:233-240



Yang Y, Huang J, Mis MA, Estacion M, Macala L, Shah P, Schulman BR, Horton DB, Dib-Hajj SD, Waxman SG. Nav1.7-A1632G mutation from a family with inherited erythromelalgia: enhanced firing of dorsal root ganglia neurons evoked by thermal stimuli. Journal of Neuroscience 2016, 36:7511-22


Geha P, Yang Y, Estacion M, Schulman BR, Tokuno H, Apkarian AV, Dib-Hajj SD, Waxman SG. Pharmacotherapy for pain in a family with inherited erythromelalgia guided by genomic analysis and functional profiling. JAMA Neurology 2016, 73:659-67

(Yale News: “personalized treatment for chronic pain closer to reality”.)



Han C, Yang Y, de Greef BT, Hoeijmakers JG, Gerrits MM, Verhamme C, Qu J, Lauria G, Merkies IS, Faber CG, Dib-Hajj SD, Waxman SG. The Domain II S4-S5 linker in Nav1.9: a missense mutation enhances activation, impairs fast inactivation, and produces human painful neuropathy. NeuroMolecular Medicine 2015, 17:158-169


Li SS, Cui N, Yang Y, Trower TC, Wei YM, Wu Y, Zhang S, Jin X, Jiang C. Impairment of the vascular KATP channel imposes fatal susceptibility to experimental diabetes due to multi-organ injuries. Journal of Cellular Physiology 2015, 230:2915-26



Huang J&, Yang Y&, Dib-Hajj SD, van Es M, Zhao P, Salomon J, Drenth JP, Waxman SG. Depolarized inactivation overcomes impaired activation to produce DRG neuron hyperexcitability in a Nav1.7 mutation in a patient with distal limb pain. Journal of Neuroscience 2014, 34(37):12328-40 (&, Equal contribution)


Yang Y*, Jin X, Jiang C. S-glutathionylation of ion channels: insights into the regulation of channel functions, thiol modification crosstalk, and mechanosensing. Antioxidants & Redox Signaling 2014, 20(6):937-51 (*, Corresponding author)


Yang Y*, Konduru AS, Cui N, Yu L, Trower TC, Shi W, Shi Y, Jiang C. Acute exposure of methylglyoxal leads to activation of KATP channel expressed in HEK293 cells. Acta Pharmacologica Sinica (a Nature Publishing Group journal) 2014, 35:58-64 (*, Corresponding author)



Yang Y&, Vasylyev DV&, Dib-Hajj F, Veeramah KR, Hammer MF, Dib-Hajj SD, Waxman SG. Multi-state structural modeling and voltage-clamp analysis of epilepsy/autism mutation Kv10.2-R327H demonstrate the role of this residue in stabilizing the channel closed state. Journal of Neuroscience 2013, 33(42):16596-93 (&, Equal contribution)


Huang J, Yang Y, Zhao P, Gerrits MM, Hoeijmakers JG, Bekelaar K, Merkies IS, Faber CG, Dib-Hajj SD, Waxman SG. Small-fiber neuropathy Nav1.8 mutation shifts activation to hyperpolarized potentials and increases excitability of dorsal root ganglion neurons. Journal of Neuroscience 2013, 33(35):14087-14097


Dib-Hajj SD, Yang Y, Black JA, Waxman SG. The Nav1.7 sodium channel: from molecule to man. Nature Reviews Neuroscience 2013, 14(1): 49-62


Yang Y, Estacion M, Dib-Hajj SD, Waxman SG. Molecular architecture of a sodium channel S6 helix: radial tuning of the Nav1.7 activation gate. Journal of Biological Chemistry 2013, 288 (19): 13741-47


Estacion M, Yang Y, Dib-Hajj SD, Tyrrell L, Lin Z, Yang Y, Waxman SG. A new Nav1.7 mutation in an erythromelalgia patient. Biochemical and Biophysical Research Communications 2013, 432(1):99-104



Yang Y, Dib-Hajj SD, Zhang J, Zhang Y, Tyrrell L, Estacion M, Waxman SG. Structural modeling and mutant cycle analysis predict pharmacoresponsiveness of a Nav1.7 mutant channel. Nature Communications 2012, 3:1186

(featured in ABC News: “New Hope for Man on Fire Syndrome”; Yale News: “In a world of chronic pain, individual treatment possible”; and Cover image of Chemical & Engineering News/C&EN: “Changing the Channel”)


Shields S, Ahn HS, Yang Y, Han C, Seal R, Wood JN, Waxman SG, Dib-Hajj SD. Nav1.8 expression is not restricted to nociceptors in mouse peripheral nervous system. PAIN 2012, 153(10):2017-30


Yang Y, Li S, Konduru AS, Zhang S, Trower TC, Shi W, Cui N, Yu L, Wang Y, Zhu D, Jiang C. Prolonged exposure to methylglyoxal causes disruption of vascular KATP channel by mRNA instability. American Journal of Physiology-Cell Physiology 2012, 303(10): C1045-54


Shi W, Yang Y, Shi Y, Jiang C. KATP channel action in vascular tone regulation: From genetics to diseases. Acta Physiologica Sinica 2012, 64(1):1-13 (featured as cover image)


Jin X&, Yu L&, Wu Y, Zhang S, Shi Z, Chen X, Yang Y, Zhang X, Jiang C. S-glutathionylation underscores the modulation of the heteromeric Kir4.1-Kir5.1 channel in oxidative stress. Journal of Physiology 2012, 590(21): 5335-48 (&, Equal contribution)



Yu L&, Jin X&, Yang Y, Cui N, Jiang C. Rosiglitazone inhibits the vascular KATP channel and lowers coronary vasodilation response to isoproterenol. British Journal of Pharmacology 2011, 164(8): 2064-72 (&, Equal contribution)


Yang Y&, Shi W&, Chen X&, Cui N, Konduru AS, Shi Y, Trower TC, Jiang C. Molecular basis and structural insight of vascular KATP channel gating by S-glutathionylation. Journal of Biological Chemistry 2011, 286: 9298-307 (&, Equal contribution)


Yang Y, Shi W, Cui N, Wu Z, Jiang C. Oxidative stress inhibits KATP channel by S-glutathionylation. Journal of Biological Chemistry 2010, 285: 38641-8


Shi W, Cui N, Wu Z, Yang Y, Zhang S, Gai H, Zhu D, Jiang C. Lipopolysaccharides up-regulate Kir6.1/SUR2B channel expression and enhance vascular KATP channel activity via NF-κB-dependent signaling. Journal of Biological Chemistry 2010, 285: 3021-9



Chen F, Ren W, Yang Y, Shen D, Zong Y, Xu S, Duan Y, Qian Y, Ji Y. Reciprocal effects of conditioned medium on cultured glioma cells and neural stem cells. Journal of Clinical Neuroscience 2009, 16: 1619-23


Chen F, Qian Y, Duan Y, Ren W, Yang Y, Zhang C, Qiu Y, Ji Y. Down-regulation of 67LR reduces the migratory activity of human glioma cells in vitro. Brain Research Bulletin 2009, 79: 402-8



Yang Y, Shi Y, Guo S, Zhang S, Cui N, Shi W, Zhu D, Jiang C. PKA-dependent activation of the vascular smooth muscle isoform of KATP channels by vasoactive intestinal polypeptide and its effect on relaxation of the mesenteric resistance artery. Biochimica et Biophysica Acta-Biomembranes 2008, 1778(1): 88-96


Shi Y, Chen X, Wu Z, Shi W, Yang Y, Cui N, Jiang C, Harrison RW. cAMP-dependent protein kinase phosphorylation produces interdomain movement in SUR2B leading to activation of the vascular KATP channel. Journal of Biological Chemistry 2008, 283: 7523-30


Yang Y, Qiu Y, Ren W, Gong J, Chen F. An identification of stem cell-resembling gene expression profiles in high-grade astrocytomas. Molecular Carcinogenesis 2008, 47: 893-903


Ren W, Duan Y, Yang Y, Ji Y, Chen F. Down-regulation of Stat3 induces apoptosis of human glioma cell: a potential method to treat brain cancer. Neurological Research 2008, 30: 297-301



Shi Y, Wu Z, Cui N, Shi W, Yang Y, Zhang X, Rojas A, Ha BT, Jiang C. PKA phosphorylation of SUR2B subunit underscores vascular KATP channel activation by beta-adrenergic receptors. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2007, 293: R1205-14


Shi W, Cui N, Shi Y, Zhang X, Yang Y, Jiang C. Arginine vasopressin inhibits Kir6.1/SUR2B channel and constricts the mesenteric artery via V1a receptor and protein kinase C. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2007, 293: R191-9

Liu Y, Tong Q, Zhou Y, Lee H, Yang J, Buhring HJ, Chen YT, Ha B, Chen CX, Yang Y, Zen K. Functional elements on SIRPα IgV domain mediate cell surface binding to CD47. Journal of Molecular Biology 2007, 365: 680-93



Yang Y, Ren W, Chen F. Knockdown of Stat3 in C17.2 neural stem cells facilitates the generation of neurons: a possibility of transplantation with a low level of oncogene. NeuroReport 2006, 17: 235-8


Ren W, Guo Q, Yang Y, Chen F. bFGF and heparin but not laminin are necessary factors in the mediums that affect NSCs differentiation into cholinergic neurons. Neurological Research 2006, 28: 87-90


Chen F, Guo Q, Yang Y, Song H, Wen T. Inhibition of AF116909 gene expression enhances the differentiation of neural stem cells. Neurological Research 2005 Jul;27(5):557-61. 

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