(papers in which Dr. Yang is a corresponding author are highlighted in red)


Verma P&, Eaton M&, Kienle A, Flockerzi D, Yang Y*, Ramkrishna D*, Examining sodium and potassium channel conductances involved in hyperexcitability of chemotherapy-induced peripheral neuropathy: A mathematical and cell culture-based studyFrontiers in Computational Neuroscience. 2020 in press

Chen X, Zhang J, Song Y, Yang P, Yang Y, Huang Z, Wang K, Deficiency of anti-inflammatory cytokine IL-4 leads to neural hyperexcitability and aggravates cerebral ischemiaereperfusion injuryActa Pharmaceutica Sinica B. 2020 in press

Xenakis MN, Kapetis D, Yang Y, Heijman J, Waxman SG, Lauria G, Faber CG, Smeets HJ, Westra RL, Lindsey PJ. Cumulative hydropathic topology of a voltage-gated sodium channel at atomic resolution. Proteins. 2020 in press

Kong W, Tu X, Huang W, Yang Y, Xie Z, Huang Z. Prediction and Optimization of Nav1.7 Sodium Channel Inhibitors Based on Machine Learning and Simulated Annealing. Journal of Chemical Information and Modeling. 2020 Jun 22;60(6):2739-2753


Jin X, Chen Q, Song Y, Zheng J, Xiao K, Shao S, Fu Z, Yi M, Yang Y, Huang Z. Dopamine D2 receptors regulate the action potential threshold by modulating T-type calcium channels in stellate cells of the medial entorhinal cortex. Journal of Physiology 2019 Jul;597(13):3363-3387 

Mis MA&, Yang Y&, Tanaka BS, Gomis-Perez C, Liu S, Dib-Hajj F, Adi T, Garcia-Milian R, Schulman BR, Dib-Hajj SD, Waxman SG. Resilience to Pain: A Peripheral Component Identified Using Induced Pluripotent Stem Cells and Dynamic ClampJournal of Neuroscience 2019, 39(3):382-392 (&, equal contribution) F1000 Faculty Opinions; Pain Research Forum news: Pain-in-a-Dish Expands the Nav1.7 Reserach Menu


Mis MA, Rogers MF, Jeffries AR, Wilbrey AL, Chen L, Yang Y, Dib-Hajj S, Waxman SG, Stevens EB, Randall AD. Differential aging-related changes in neurophysiology and gene expression in IB4-positive and IB4-negative nociceptive neurons. Aging Cell 2018, e12795

Yang Y, Mis MA, Estacion M, Dib-Hajj SD, Waxman SG. Nav1.7 as a pharmacogenomics target for pain: Moving towards precision medicine. Trends in Pharmacological Sciences 2018, 39(3):258-275

Yang Y, Adi T, Effraim P, Chen L, Dib-Hajj SD, Waxman SG. Reverse pharmacogenomics: carbamazepine normalizes activation and attenuates thermal-induced hyperexcitability of sensory neurons due to Nav1.7 mutation I234T. British Journal of Pharmacology 2018, 175:2261-71


Kapetis D, Sassone J, Yang Y, Galbardi B, Xenakis MN, Westra RL, Szklarczyk R, Lindsey P, Faber CG, Gerrits M, Merkies IS, Dib-Hajj SD, Mantegazza M, Waxman SG, Lauria G. Network topology of Nav1.7 mutations in sodium channel-related painful disorders. BMC Systems Biology 2017, 11:28


Han C, Yang Y, Te Morsche RH, Drenth JP, Politei JM, Waxman SG, Dib-Hajj SD. Familial gain-of-function Nav1.9 mutation in a painful channelopathy. Journal of Neurology, Neurosurgery & Psychiatry 2017, 88:233-240



Yang Y, Huang J, Mis MA, Estacion M, Macala L, Shah P, Schulman BR, Horton DB, Dib-Hajj SD, Waxman SG. Nav1.7-A1632G mutation from a family with inherited erythromelalgia: enhanced firing of dorsal root ganglia neurons evoked by thermal stimuli. Journal of Neuroscience 2016, 36:7511-22


Geha P, Yang Y, Estacion M, Schulman BR, Tokuno H, Apkarian AV, Dib-Hajj SD, Waxman SG. Pharmacotherapy for pain in a family with inherited erythromelalgia guided by genomic analysis and functional profiling. JAMA Neurology 2016, 73:659-67

(Yale News: “personalized treatment for chronic pain closer to reality”.)



Han C, Yang Y, de Greef BT, Hoeijmakers JG, Gerrits MM, Verhamme C, Qu J, Lauria G, Merkies IS, Faber CG, Dib-Hajj SD, Waxman SG. The Domain II S4-S5 linker in Nav1.9: a missense mutation enhances activation, impairs fast inactivation, and produces human painful neuropathy. NeuroMolecular Medicine 2015, 17:158-169


Li SS, Cui N, Yang Y, Trower TC, Wei YM, Wu Y, Zhang S, Jin X, Jiang C. Impairment of the vascular KATP channel imposes fatal susceptibility to experimental diabetes due to multi-organ injuries. Journal of Cellular Physiology 2015, 230:2915-26



Huang J&, Yang Y&, Dib-Hajj SD, van Es M, Zhao P, Salomon J, Drenth JP, Waxman SG. Depolarized inactivation overcomes impaired activation to produce DRG neuron hyperexcitability in a Nav1.7 mutation in a patient with distal limb pain. Journal of Neuroscience 2014, 34(37):12328-40 (&, Equal contribution)


Yang Y*, Jin X, Jiang C. S-glutathionylation of ion channels: insights into the regulation of channel functions, thiol modification crosstalk, and mechanosensing. Antioxidants & Redox Signaling 2014, 20(6):937-51 (*, Corresponding author)


Yang Y*, Konduru AS, Cui N, Yu L, Trower TC, Shi W, Shi Y, Jiang C. Acute exposure of methylglyoxal leads to activation of KATP channel expressed in HEK293 cells. Acta Pharmacologica Sinica (a Nature Publishing Group journal) 2014, 35:58-64 (*, Corresponding author)



Yang Y&, Vasylyev DV&, Dib-Hajj F, Veeramah KR, Hammer MF, Dib-Hajj SD, Waxman SG. Multi-state structural modeling and voltage-clamp analysis of epilepsy/autism mutation Kv10.2-R327H demonstrate the role of this residue in stabilizing the channel closed state. Journal of Neuroscience 2013, 33(42):16596-93 (&, Equal contribution)


Huang J, Yang Y, Zhao P, Gerrits MM, Hoeijmakers JG, Bekelaar K, Merkies IS, Faber CG, Dib-Hajj SD, Waxman SG. Small-fiber neuropathy Nav1.8 mutation shifts activation to hyperpolarized potentials and increases excitability of dorsal root ganglion neurons. Journal of Neuroscience 2013, 33(35):14087-14097


Dib-Hajj SD, Yang Y, Black JA, Waxman SG. The Nav1.7 sodium channel: from molecule to man. Nature Reviews Neuroscience 2013, 14(1): 49-62


Yang Y, Estacion M, Dib-Hajj SD, Waxman SG. Molecular architecture of a sodium channel S6 helix: radial tuning of the Nav1.7 activation gate. Journal of Biological Chemistry 2013, 288 (19): 13741-47


Estacion M, Yang Y, Dib-Hajj SD, Tyrrell L, Lin Z, Yang Y, Waxman SG. A new Nav1.7 mutation in an erythromelalgia patient. Biochemical and Biophysical Research Communications 2013, 432(1):99-104



Yang Y, Dib-Hajj SD, Zhang J, Zhang Y, Tyrrell L, Estacion M, Waxman SG. Structural modeling and mutant cycle analysis predict pharmacoresponsiveness of a Nav1.7 mutant channel. Nature Communications 2012, 3:1186

(featured in ABC News: “New Hope for Man on Fire Syndrome”; Yale News: “In a world of chronic pain, individual treatment possible”; and Cover image of Chemical & Engineering News/C&EN: “Changing the Channel”)


Shields S, Ahn HS, Yang Y, Han C, Seal R, Wood JN, Waxman SG, Dib-Hajj SD. Nav1.8 expression is not restricted to nociceptors in mouse peripheral nervous system. PAIN 2012, 153(10):2017-30


Yang Y, Li S, Konduru AS, Zhang S, Trower TC, Shi W, Cui N, Yu L, Wang Y, Zhu D, Jiang C. Prolonged exposure to methylglyoxal causes disruption of vascular KATP channel by mRNA instability. American Journal of Physiology-Cell Physiology 2012, 303(10): C1045-54


Shi W, Yang Y, Shi Y, Jiang C. KATP channel action in vascular tone regulation: From genetics to diseases. Acta Physiologica Sinica 2012, 64(1):1-13 (featured as cover image)


Jin X&, Yu L&, Wu Y, Zhang S, Shi Z, Chen X, Yang Y, Zhang X, Jiang C. S-glutathionylation underscores the modulation of the heteromeric Kir4.1-Kir5.1 channel in oxidative stress. Journal of Physiology 2012, 590(21): 5335-48 (&, Equal contribution)



Yu L&, Jin X&, Yang Y, Cui N, Jiang C. Rosiglitazone inhibits the vascular KATP channel and lowers coronary vasodilation response to isoproterenol. British Journal of Pharmacology 2011, 164(8): 2064-72 (&, Equal contribution)


Yang Y&, Shi W&, Chen X&, Cui N, Konduru AS, Shi Y, Trower TC, Jiang C. Molecular basis and structural insight of vascular KATP channel gating by S-glutathionylation. Journal of Biological Chemistry 2011, 286: 9298-307 (&, Equal contribution)


Yang Y, Shi W, Cui N, Wu Z, Jiang C. Oxidative stress inhibits KATP channel by S-glutathionylation. Journal of Biological Chemistry 2010, 285: 38641-8


Shi W, Cui N, Wu Z, Yang Y, Zhang S, Gai H, Zhu D, Jiang C. Lipopolysaccharides up-regulate Kir6.1/SUR2B channel expression and enhance vascular KATP channel activity via NF-κB-dependent signaling. Journal of Biological Chemistry 2010, 285: 3021-9



Chen F, Ren W, Yang Y, Shen D, Zong Y, Xu S, Duan Y, Qian Y, Ji Y. Reciprocal effects of conditioned medium on cultured glioma cells and neural stem cells. Journal of Clinical Neuroscience 2009, 16: 1619-23


Chen F, Qian Y, Duan Y, Ren W, Yang Y, Zhang C, Qiu Y, Ji Y. Down-regulation of 67LR reduces the migratory activity of human glioma cells in vitro. Brain Research Bulletin 2009, 79: 402-8



Yang Y, Shi Y, Guo S, Zhang S, Cui N, Shi W, Zhu D, Jiang C. PKA-dependent activation of the vascular smooth muscle isoform of KATP channels by vasoactive intestinal polypeptide and its effect on relaxation of the mesenteric resistance artery. Biochimica et Biophysica Acta-Biomembranes 2008, 1778(1): 88-96


Shi Y, Chen X, Wu Z, Shi W, Yang Y, Cui N, Jiang C, Harrison RW. cAMP-dependent protein kinase phosphorylation produces interdomain movement in SUR2B leading to activation of the vascular KATP channel. Journal of Biological Chemistry 2008, 283: 7523-30


Yang Y, Qiu Y, Ren W, Gong J, Chen F. An identification of stem cell-resembling gene expression profiles in high-grade astrocytomas. Molecular Carcinogenesis 2008, 47: 893-903


Ren W, Duan Y, Yang Y, Ji Y, Chen F. Down-regulation of Stat3 induces apoptosis of human glioma cell: a potential method to treat brain cancer. Neurological Research 2008, 30: 297-301



Shi Y, Wu Z, Cui N, Shi W, Yang Y, Zhang X, Rojas A, Ha BT, Jiang C. PKA phosphorylation of SUR2B subunit underscores vascular KATP channel activation by beta-adrenergic receptors. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2007, 293: R1205-14


Shi W, Cui N, Shi Y, Zhang X, Yang Y, Jiang C. Arginine vasopressin inhibits Kir6.1/SUR2B channel and constricts the mesenteric artery via V1a receptor and protein kinase C. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2007, 293: R191-9

Liu Y, Tong Q, Zhou Y, Lee H, Yang J, Buhring HJ, Chen YT, Ha B, Chen CX, Yang Y, Zen K. Functional elements on SIRPα IgV domain mediate cell surface binding to CD47. Journal of Molecular Biology 2007, 365: 680-93



Yang Y, Ren W, Chen F. Knockdown of Stat3 in C17.2 neural stem cells facilitates the generation of neurons: a possibility of transplantation with a low level of oncogene. NeuroReport 2006, 17: 235-8


Ren W, Guo Q, Yang Y, Chen F. bFGF and heparin but not laminin are necessary factors in the mediums that affect NSCs differentiation into cholinergic neurons. Neurological Research 2006, 28: 87-90


Chen F, Guo Q, Yang Y, Song H, Wen T. Inhibition of AF116909 gene expression enhances the differentiation of neural stem cells. Neurological Research 2005 Jul;27(5):557-61. 

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updated: 01-06-2020