Targeted gene therapy alleviates epilepsy and hyperexcitability in models of Scn2a deficiency

Zaiyang Zhang&†, Jingliang Zhang&†, Xiaoling Chen&†, Brody A Deming†, Shivam Kant†, Purba Mandal†, Harish Kothandaraman, Phillip J SanMiguel, Manasi S Halurkar†, Akila D Abeyaratna†, Morgan J Robinson†, Yuanrui Zhao†, Yuliia Vitko, Ronald P Gaykema, Chongli Yuan, Nadia A Lanman, Matthew T Tegtmeyer, Dan Wang, Guangping Gao, Riyi Shi, Edward Perez-Reyes, Yang Yang*

bioRxiv 2025 (Journal of Clinical Investigation, accepted in principle)

Restoration of excitation/inhibition balance enhances neuronal signal-to-noise ratio and rescues social deficits in autism-associated Scn2a-deficiency

Jingliang Zhang&†, Muriel Eaton&†, Xiaoling Chen&†, Yuanrui Zhao†, Shivam Kant†, Brody A. Deming†, Kothandaraman Harish, Huynhvi P. Nguyen†, Yue Shu†, Shirong Lai†, Jiaxiang Wu†, Zhefu Que†, Kyle W. Wettschurack†, Zaiyang Zhang†, Tiange Xiao†, Manasi S. Halurkar†, Maria I. Olivero-Acosta†, Ye-Eun Yoo†, Nadia A. Lanman, Wendy A. Koss, William C. Skarnes, Yang Yang*.

bioRxiv 2025 (in submission)

Near 100% genome editing efficiency with a one-step all RNA prime editing system in a human reporter iPSC line

​Kyle Wettschurack&†, William C. Skarnes&, Enrica Pellegrino, Morgan Robinson†, Yang Yang*.

bioRxiv 2025 (in revision at Cell Stem Cell)

FEATUREDAutism-associated SCN2A deficiency disrupts cortico-striatal circuitry in human brain assembloids

Xiaoling Chen&†, Jingliang Zhang&†, Jiaxiang Wu†, Morgan J. Robinson†, Harish Kothandaraman, Ye-Eun Yoo†, Iria M. Gonzalez Dopeso-Reyes, Thomas D. Buffenoir, Manasi S. Halurkar†, Zaiyang Zhang†, Muhan Wang†, Erin N. Creager†, Yuanrui Zhao†, Maria I. Olivero-Acosta†, Kyle W. Wettschurack†, Zhefu Que†, Chongli Yuan, Allison J. Schaser, Nadia A. Lanman, Jean-Christophe Rochet, William C. Skarnes, Eric J. Kremer, Yang Yang*.

Neuron, 2026, in press

Epilepsy-Associated SCN2A-L1342P Mutation Drives Network Hyperexcitability and Widespread Transcriptomic Changes in Human Cortical Organoids

Maria I. Olivero-Acosta&†, Morgan Robinson&†, Zhefu Que†, Zaiyang Zhang†, Hope Elizabeth Harlow†, Vinayak Shankar†, Seoyong Hong†, Muhan Wang†, Conrad M. Otterbacher†, Hina Kadono†, Manasi Halurkar†, Harish Kothandaraman, Nadia Lanman, Trang Nguyen†, Kyle Wettschurack†, Benjamin Zirkle†, Layan Yunis†, Ningren Cui†, Xiaoling Chen†, Jingliang Zhang†, Jiaxiang Wu†, William C. Skarnes, Chongli Yuan, Feng Guo, Megan Abbott, Yang Yang*​

Epilepsia, 2026, in press

Single-nucleus transcriptomics reveal disrupted pathways in the prefrontal cortex of Scn2a-deficient mice

Ye-Eun Yoo&†, Zaiyang Zhang&†, Purba Mandal†, Zhengkuan Tang, Jingliang Zhang†, Xiaoling Chen†, Morgan J. Robinson†, Muriel Eaton†, Brody A. Deming†, Manasi S. Halurkar†, Harish Kothandaraman, Luke C. Dabin, Boyu Jiang, Hongyu Gao, Chongli Yuan, Nadia A. Lanman, Yunlong Liu, Jungsu Kim, Priyanka Baloni, Yang Yang*

Translational Psychiatry, 2026, in press.

FEATUREDHuman microglia in brain assembloids display region-specific diversity and respond to hyperexcitable neurons carrying SCN2A mutation

Jiaxiang Wu&†, Xiaoling Chen&†, Jingliang Zhang&†, Kyle Wettschurack†, Morgan Robinson†, Weihao Li, Yuanrui Zhao†, Ye-Eun Yoo†, Brody A. Deming†, Akila D. Abeyaratna†, Zhefu Que†, Dongshu Du, Matthew Tegtmeyer, Chongli Yuan, William C. Skarnes, Jean-Christophe Rochet, Long-Jun Wu, Yang Yang*

Science Advances, 2026.

REVIEWPrecision medicine for sodium channelopathy-related autism and epilepsy

Morgan Robinson†, Kyle Wettschurack†, Manasi S Halurkar†, Xiaoling Chen†, Zaiyang Zhang†, Jingliang Zhang†, Yang Yang*.

Trends in Molecular Medicine, 2026.

Cover image

An engineered UGA suppressor tRNA gene for disease-agnostic AAV delivery

Mengyao Xu, Hao Liu, Jiaming Wang, Andre FC Vieira, Xuntao Zhou, Nan Liu, Jialing Liang, Ailing Du, Xiupeng Chen, Ruxiao Xing, Yang Yang, Maria P. Gonzalez-Perez, Vikas Kumar, Dan Wang*

Nature Biotechnology, 2026

Spatial Lipidomics Reveals Region-Specific Lipid Remodeling in Scn2a-deficient Mouse Brain

Alyssa Moore&, Xiaoling Chen&†, Emerson Hernly, Jingliang Zhang†, Yang Yang, Julia Laskin*.

ACS Chemical Neuroscience, 2026.

Chemogenetic inhibition of the cortical amygdala reduces alcohol intake and decreases disrupted thalamic connectivity during alcohol withdrawal in dependent female mice

Tiange Xiao, Xi Cheng, Jingliang Zhang†, Yueyi Chen, Zhefu Que†, Xiaoling Chen†, Danielle McAuliffe, Alyssa Boisvert, Yang Yang, Alexander Chubykin, Adam Kimbrough

Neuropharmacology, 2026

NEUROVIEWWhat we can learn from the first personalized CRISPR-treated baby to tackle genetic brain disorders

Yang Yang*.

Neuron, 2025 Nov 19;113(22):3697-3702.

Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation

Zhefu Que&†, Maria I. Olivero-Acosta&†, Morgan Robinson†, Ian Chen†, Jingliang Zhang†, Kyle Wettschurack†, Jiaxiang Wu†, Tiange Xiao†, Conrad M. Otterbacher†, Vinayak Shankar†, Hope Harlow†, Seoyong Hong†, Benjamin Zirkle†, Muhan Wang†, Ningren Cui†, Purba Mandal†, Xiaoling Chen†, Brody Deming†, Manasi Halurkar†, Yuanrui Zhao†, Jean-Christophe Rochet, Ranjie Xu, Amy L. Brewster, Long-Jun Wu, Chongli Yuan, William C. Skarnes, and Yang Yang*.

Journal of Neuroscience, 2025

Cover Image

Alzheimer’s disease patient brain extracts induce multiple pathologies in novel vascularized neuroimmune organoids for disease modeling and drug discovery

Yanru Ji, Xiaoling Chen†, Zhen Wang, Connor Joseph Meek, Jenna Lillie McLean, Yang Yang, Chongli Yuan, Jean-Christophe Rochet, Fei Liu & Ranjie Xu*.

Molecular Psychiatry 2025

The DEC2-SCN2A axis is essential for the anticonvulsant effects of cannabidiol by modulating neuronal plasticity

Huifang Song&, Yifan Wang&, Lili Wang, Chang Guo, Shiqi Liu, Yi Rong, Jiawen Tian, Chao Peng, Yuying Shao, Zhixiong Ma, Na Li, Jingliang Zhang, Zijun Peng, Xu Yan, Hangwei Fa, Xinyue Ma, Jie Dong, Jinping Ji, Chen Yang, Haocheng Chen, Jing Liang, Qi Sun*, Yang Yang*, Weining Ma*, Zhuo Huang*.

Advanced Science, 2025.

Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids

Wu J&†, Zhang J&†, Chen X&†, Que Z†, Wettschurack K†, Deming B†, Ascosta M†, Cui N†, Eaton M†, Zhao Y†, Halurkar M†, Purba M†, Chen I†, Xiao T†, Suzuki M†, Yuan C, Xu R, Koss W, Du D, Chen F, Wu LJ, Yang Y*

Molecular Psychiatry, 2024.

News coverage: Previewed in the Transmitter/Spectrum | Autism Research News: Microglial overreaction to atypical neurons may drive autism: In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.

Coupling of Slack and Nav1.6 sensitizes Slack to quinidine blockade and guides antiseizure strategy development,

Yuan T, Wang Y, Jing Y, Xu S, Zhang H, Chen Q, Li N, Ma X, Song H, Peng C, Yang H, Geng Z, Dong J, Duan G, Sun Q, Yang Y, Yang F, Huang Z*

eLife. 2024 version of record.

Developmental Pb exposure increases AD risk via altered intracellular Ca2+ homeostasis in hiPSC-derived cortical neurons,

Xie J, Wu S, Szadowski H, Min S, Yang Y, Bowman AB, Rochet JC, Freeman JL, Yuan C*

Journal of Biological Chemistry. 2023.

Acute transcriptomic and epigenetic alterations at T12 after rat T10 spinal cord contusive injury,

Xie J, Herr S, Ma D, Wu S, Zhao H, Sun S, Ma Z, Chan MY, Li K, Yang Y, Huang F, Shi R, Yuan C*

Molecular Neurobiology. 2023.

Deficiency of autism-related Scn2a gene in mice disrupts sleep patterns and circadian rhythms

Ma Z†, Eaton M†, Liu Y, Zhang J†, Chen X†, Tu X, Shi Y, Que Z†, Wettschurack K†, Zhang Z†, Shi Y, Chen Y, Kimbrough A, Lanman NA, Schust L, Huang Z*, Yang Y*

Neurobiology of Disease. 2022.

Hyperexcitability and pharmacological responsiveness of cortical neurons derived from human iPSCs carrying epilepsy-associated sodium channel Nav1.2-L1342P genetic variant

Que Z&†, Olivero-Acosta MI&†, Zhang J†, Eaton M†, Tukker AM, Chen X†, Xiao T†, Wu J†, Xie J, Wettschurack K†, Yunis L†, Shafer MJ†, Schaber JA, Rochet JC, Bowman AB, Yuan C, Huang Z, Hu CD, Trader DJ, Skarnes WC, Yang Y*.

Journal of Neuroscience, an official journal of the Society for Neuroscience. 2021.

Featured on the Cover, and previewed in This Week in The Journal

Severe deficiency of the voltage-gated sodium channel Nav1.2 elevates neuronal excitability in adult mice

Zhang J&†, Chen X&†, Eaton M†, Wu J†, Ma Z†, Lai S†, Park A†, Ahmad TS†, Que Z†, Lee JH†, Xiao T†, Li Y†, Wang Y†, Olivero-Acosta MI†, Schaber JA, Jayant K, Yuan C, Huang Z, Lanman NA, Skarnes WC, Yang Y*.

Cell Reports. 2021.

Spotlight preview in Trends in Neurosciences -- The NaVy paradox: reducing sodium currents increases excitability.

Multi-electrode array of sensory neurons as an in vitro platform to identify the nociceptive response to pharmaceutical buffer systems of injectable biologics,

Eaton M†, Que Z†, Zhang J†, Beck K, Shi R, McDermott J, Ladisch M*, Yang Y*

Pharmaceutical Research, an official journal of the American Association of Pharmaceutical Scientists. 2021.

Featured on the Cover.

Generation and basic characterization of a gene-trap knockout mouse model of Scn2a with a substantial reduction of voltage-gated sodium channel Nav1.2 expression

Eaton M†, Zhang J†, Ma Z†, Park AC†, Lietzke E†, Romero CM†, Liu Y†, Coleman ER†, Chen X†, Xiao T†, Que Z†, Lai S†, Wu J†, Lee JH†, Palant S†, Nguyen HP†, Huang Z, Skarnes WC, Koss WA, Yang Y*

Genes, Brain and Behavior, an official journal of the International Behavioural and Neural Genetics Society. 2021.

Featured on the Cover.

PKA-RIIβ autophosphorylation modulates PKA activity and seizure phenotypes in mice

Zhang J&, Zhang C&, Chen X, Wang B, Ma W, Yang Y, Zheng R and Huang Z

Communications Biology. 2021.

Hydropathicity-based prediction of pain-causing NaV1.7 variants,

Xenakis MN, Kapetis D, Yang Y, Gerrits MM, Heijman J, Waxman SG, Lauria G, Faber CG, Westra RL, Lindsey PJ, Smeets HJ

BMC Bioinformatics. 2021.

Non-extensitivity and criticality of atomic hydropathicity around a voltage-gated sodium channel's pore: a modeling study,

Xenakis MN, Kapetis D, Yang Y, Heijman J, Waxman SG, Lauria G, Faber CG, Smeets HJ, Lindsey PJ, Westra RL

Journal of Biological Physics. 2021.

Examining sodium and potassium channel conductances involved in hyperexcitability of chemotherapy-induced peripheral neuropathy: A mathematical and cell culture-based study

Verma P&, Eaton M&, Kienle A, Flockerzi D, Yang Y*, Ramkrishna D*

Frontiers in Computational Neuroscience. 2020

Cumulative hydropathic topology of a voltage-gated sodium channel at atomic resolution

Xenakis MN, Kapetis D, Yang Y, Heijman J, Waxman SG, Lauria G, Faber CG, Smeets HJ, Westra RL, Lindsey PJ

Proteins. 2020

Deficiency of anti-inflammatory cytokine IL-4 leads to neural hyperexcitability and aggravates cerebral ischemia-reperfusion injury

Chen X, Zhang J, Song Y, Yang P, Yang Y, Huang Z, Wang K

Acta Pharmaceutica Sinica B. 2020

Prediction and Optimization of Nav1.7 Sodium Channel Inhibitors Based on Machine Learning and Simulated Annealing

Kong W, Tu X, Huang W, Yang Y, Xie Z, Huang Z

Journal of Chemical Information and Modeling. 2020

Deletion of Kv10.2 causes abnormal dendritic arborization and epilepsy susceptibility

Liu Y, Tang Y, Yang J, Du D, Yang Y, Chen F

Neurochemical Research. 2020

Dopamine D2 receptors regulate the action potential threshold by modulating T-type calcium channels in stellate cells of the medial entorhinal cortex

Jin X, Chen Q, Song Y, Zheng J, Xiao K, Shao S, Fu Z, Yi M, Yang Y, Huang Z

Journal of Physiology 2019

Resilience to Pain: A Peripheral Component Identified Using Induced Pluripotent Stem Cells and Dynamic Clamp

Mis MA&, Yang Y&, Tanaka BS, Gomis-Perez C, Liu S, Dib-Hajj F, Adi T, Garcia-Milian R, Schulman BR, Dib-Hajj SD, Waxman SG

Journal of Neuroscience 2019.

F1000 Faculty Opinions; Pain Research Forum news: Pain-in-a-Dish Expands the Nav1.7 Research Menu

Differential aging-related changes in neurophysiology and gene expression in IB4-positive and IB4-negative nociceptive neurons.

Mis MA, Rogers MF, Jeffries AR, Wilbrey AL, Chen L, Yang Y, Dib-Hajj S, Waxman SG, Stevens EB, Randall AD

Aging Cell 2018

Nav1.7 as a pharmacogenomics target for pain: Moving towards precision medicine.

Yang Y, Mis MA, Estacion M, Dib-Hajj SD, Waxman SG

Trends in Pharmacological Sciences 2018

Reverse pharmacogenomics: carbamazepine normalizes activation and attenuates thermal-induced hyperexcitability of sensory neurons due to Nav1.7 mutation I234T.

Yang Y, Adi T, Effraim P, Chen L, Dib-Hajj SD, Waxman SG

British Journal of Pharmacology 2018

Network topology of Nav1.7 mutations in sodium channel-related painful disorders.

Kapetis D, Sassone J, Yang Y, Galbardi B, Xenakis MN, Westra RL, Szklarczyk R, Lindsey P, Faber CG, Gerrits M, Merkies IS, Dib-Hajj SD, Mantegazza M, Waxman SG, Lauria G

BMC Systems Biology 2017

Familial gain-of-function Nav1.9 mutation in a painful channelopathy.

Han C, Yang Y, Te Morsche RH, Drenth JP, Politei JM, Waxman SG, Dib-Hajj SD

Journal of Neurology, Neurosurgery & Psychiatry 2017

Nav1.7-A1632G mutation from a family with inherited erythromelalgia: enhanced firing of dorsal root ganglia neurons evoked by thermal stimuli.

Yang Y, Huang J, Mis MA, Estacion M, Macala L, Shah P, Schulman BR, Horton DB, Dib-Hajj SD, Waxman SG

Journal of Neuroscience 2016, 36:7511-22

Pharmacotherapy for pain in a family with inherited erythromelalgia guided by genomic analysis and functional profiling.

Geha P, Yang Y, Estacion M, Schulman BR, Tokuno H, Apkarian AV, Dib-Hajj SD, Waxman SG

JAMA Neurology 2016, 73:659-67

(Yale News: “personalized treatment for chronic pain closer to reality”.)

The Domain II S4-S5 linker in Nav1.9: a missense mutation enhances activation, impairs fast inactivation, and produces human painful neuropathy.

Han C, Yang Y, de Greef BT, Hoeijmakers JG, Gerrits MM, Verhamme C, Qu J, Lauria G, Merkies IS, Faber CG, Dib-Hajj SD, Waxman SG

NeuroMolecular Medicine 2015, 17:158-169

Impairment of the vascular KATP channel imposes fatal susceptibility to experimental diabetes due to multi-organ injuries.

Li SS, Cui N, Yang Y, Trower TC, Wei YM, Wu Y, Zhang S, Jin X, Jiang C

Journal of Cellular Physiology 2015, 230:2915-26

Depolarized inactivation overcomes impaired activation to produce DRG neuron hyperexcitability in a Nav1.7 mutation in a patient with distal limb pain.

Huang J&, Yang Y&, Dib-Hajj SD, van Es M, Zhao P, Salomon J, Drenth JP, Waxman SG

Journal of Neuroscience 2014, 34(37):12328-40

S-glutathionylation of ion channels: insights into the regulation of channel functions, thiol modification crosstalk, and mechanosensing.

Yang Y*, Jin X, Jiang C

Antioxidants & Redox Signaling 2014, 20(6):937-51

Acute exposure of methylglyoxal leads to activation of KATP channel expressed in HEK293 cells.

Yang Y*, Konduru AS, Cui N, Yu L, Trower TC, Shi W, Shi Y, Jiang C

Acta Pharmacologica Sinica (a Nature Publishing Group journal) 2014, 35:58-64

Multi-state structural modeling and voltage-clamp analysis of epilepsy/autism mutation Kv10.2-R327H demonstrate the role of this residue in stabilizing the channel closed state.

Yang Y&, Vasylyev DV&, Dib-Hajj F, Veeramah KR, Hammer MF, Dib-Hajj SD, Waxman SG

Journal of Neuroscience 2013, 33(42):16596-93

Small-fiber neuropathy Nav1.8 mutation shifts activation to hyperpolarized potentials and increases excitability of dorsal root ganglion neurons.

Huang J, Yang Y, Zhao P, Gerrits MM, Hoeijmakers JG, Bekelaar K, Merkies IS, Faber CG, Dib-Hajj SD, Waxman SG

Journal of Neuroscience 2013, 33(35):14087-14097

The Nav1.7 sodium channel: from molecule to man.

Dib-Hajj SD, Yang Y, Black JA, Waxman SG

Nature Reviews Neuroscience 2013, 14(1): 49-62

Molecular architecture of a sodium channel S6 helix: radial tuning of the Nav1.7 activation gate.

Yang Y, Estacion M, Dib-Hajj SD, Waxman SG

Journal of Biological Chemistry 2013, 288 (19): 13741-47

A new Nav1.7 mutation in an erythromelalgia patient.

Estacion M, Yang Y, Dib-Hajj SD, Tyrrell L, Lin Z, Yang Y, Waxman SG

Biochemical and Biophysical Research Communications 2013, 432(1):99-104

Structural modeling and mutant cycle analysis predict pharmacoresponsiveness of a Nav1.7 mutant channel.

Yang Y, Dib-Hajj SD, Zhang J, Zhang Y, Tyrrell L, Estacion M, Waxman SG

Nature Communications 2012, 3:1186

(featured in ABC News: “New Hope for Man on Fire Syndrome”; Yale News: “In a world of chronic pain, individual treatment possible”; and Cover image of Chemical & Engineering News/C&EN: “Changing the Channel”)

Nav1.8 expression is not restricted to nociceptors in mouse peripheral nervous system.

Shields S, Ahn HS, Yang Y, Han C, Seal R, Wood JN, Waxman SG, Dib-Hajj SD

PAIN 2012, 153(10):2017-30

Prolonged exposure to methylglyoxal causes disruption of vascular KATP channel by mRNA instability.

Yang Y, Li S, Konduru AS, Zhang S, Trower TC, Shi W, Cui N, Yu L, Wang Y, Zhu D, Jiang C

American Journal of Physiology-Cell Physiology 2012, 303(10): C1045-54

KATP channel action in vascular tone regulation: From genetics to diseases.

Shi W, Yang Y, Shi Y, Jiang C

Acta Physiologica Sinica 2012, 64(1):1-13

Featured as cover image

S-glutathionylation underscores the modulation of the heteromeric Kir4.1-Kir5.1 channel in oxidative stress.

Jin X&, Yu L&, Wu Y, Zhang S, Shi Z, Chen X, Yang Y, Zhang X, Jiang C

Journal of Physiology 2012, 590(21): 5335-48

Rosiglitazone inhibits the vascular KATP channel and lowers coronary vasodilation response to isoproterenol.

Yu L&, Jin X&, Yang Y, Cui N, Jiang C

British Journal of Pharmacology 2011, 164(8): 2064-72

Molecular basis and structural insight of vascular KATP channel gating by S-glutathionylation.

Yang Y&, Shi W&, Chen X&, Cui N, Konduru AS, Shi Y, Trower TC, Jiang C

Journal of Biological Chemistry 2011, 286: 9298-307

Oxidative stress inhibits KATP channel by S-glutathionylation.

Yang Y, Shi W, Cui N, Wu Z, Jiang C

Journal of Biological Chemistry 2010, 285: 38641-8

Lipopolysaccharides up-regulate Kir6.1/SUR2B channel expression and enhance vascular KATP channel activity via NF-κB-dependent signaling.

Shi W, Cui N, Wu Z, Yang Y, Zhang S, Gai H, Zhu D, Jiang C

Journal of Biological Chemistry 2010, 285: 3021-9

Reciprocal effects of conditioned medium on cultured glioma cells and neural stem cells.

Chen F, Ren W, Yang Y, Shen D, Zong Y, Xu S, Duan Y, Qian Y, Ji Y

Journal of Clinical Neuroscience 2009, 16: 1619-23

Down-regulation of 67LR reduces the migratory activity of human glioma cells in vitro.

Chen F, Qian Y, Duan Y, Ren W, Yang Y, Zhang C, Qiu Y, Ji Y

Brain Research Bulletin 2009, 79: 402-8

PKA-dependent activation of the vascular smooth muscle isoform of KATP channels by vasoactive intestinal polypeptide and its effect on relaxation of the mesenteric resistance artery.

Yang Y, Shi Y, Guo S, Zhang S, Cui N, Shi W, Zhu D, Jiang C

Biochimica et Biophysica Acta-Biomembranes 2008, 1778(1): 88-96

cAMP-dependent protein kinase phosphorylation produces interdomain movement in SUR2B leading to activation of the vascular KATP channel.

Shi Y, Chen X, Wu Z, Shi W, Yang Y, Cui N, Jiang C, Harrison RW

Journal of Biological Chemistry 2008, 283: 7523-30

An identification of stem cell-resembling gene expression profiles in high-grade astrocytomas.

Yang Y, Qiu Y, Ren W, Gong J, Chen F

Molecular Carcinogenesis 2008, 47: 893-903

Down-regulation of Stat3 induces apoptosis of human glioma cell: a potential method to treat brain cancer.

Ren W, Duan Y, Yang Y, Ji Y, Chen F

Neurological Research 2008, 30: 297-301

PKA phosphorylation of SUR2B subunit underscores vascular KATP channel activation by beta-adrenergic receptors.

Shi Y, Wu Z, Cui N, Shi W, Yang Y, Zhang X, Rojas A, Ha BT, Jiang C

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2007, 293: R1205-14

Arginine vasopressin inhibits Kir6.1/SUR2B channel and constricts the mesenteric artery via V1a receptor and protein kinase C.

Shi W, Cui N, Shi Y, Zhang X, Yang Y, Jiang C

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2007, 293: R191-9

Functional elements on SIRPα IgV domain mediate cell surface binding to CD47.

Liu Y, Tong Q, Zhou Y, Lee H, Yang J, Buhring HJ, Chen YT, Ha B, Chen CX, Yang Y, Zen K

Journal of Molecular Biology 2007, 365: 680-93

Knockdown of Stat3 in C17.2 neural stem cells facilitates the generation of neurons: a possibility of transplantation with a low level of oncogene.

Yang Y, Ren W, Chen F

NeuroReport 2006, 17: 235-8

bFGF and heparin but not laminin are necessary factors in the medium that affect NSCs differentiation into cholinergic neurons.

Ren W, Guo Q, Yang Y, Chen F

Neurological Research 2006, 28: 87-90

Inhibition of AF116909 gene expression enhances the differentiation of neural stem cells.

Chen F, Guo Q, Yang Y, Song H, Wen T

Neurological Research 2005 Jul;27(5):557-61.