Yang Yang, PhD is an assistant professor in the Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University College of Pharmacy, also affiliated with Purdue Institute for Integrative Neuroscience. Dr. Yang graduated with dual bachelor’s degrees (B.S.: Life Sciences and B.A.: Sociology) from Shanghai University. Dr. Yang completed a PhD degree at Georgia State University under the mentorship of Dr. Chun Jiang. Dr. Yang then moved to Yale University School of Medicine as a postdoctoral fellow for three years under the mentorship of Dr. Stephen Waxman, studying pharmacogenetics of chronic pain syndromes. He was promoted to Associate Research Scientist and led a small team to use iPSCs-derived sensory neurons to establish "pain-in-a-dish" model. Dr. Yang joined the faculty of Purdue University as an Assistant Professor in 2017. Yang is the son of Qingshi Yang and cancer-fighting hero Jianbei Zang. Yang was born in Shanghai, China, and supports Asian American Awareness.
Research in Y-lab focuses on diseases of the nervous system, cancer and its complications. Many neurological and psychiatric diseases are channelopathies, which are resulted from ion channels dysfunction. Ion channels are pore-forming membrane proteins that allow ions to pass through the cell membrane, controlling many indispensable functions of cells, including the generation of action potentials in neurons. Channelopathies, often resulted from inherited or de novo mutations, are responsible for a variety of diseases including chronic pain, neuropathy, epilepsy and autism.
Using state-of-the-art technologies (structural modeling, patch-clamp recordings, multi-electrode array recordings, live cell imaging, induced pluripotent stem cells, CRISPR-mediated genome-editing, and transgenic rodent models), Y-lab aims to build new disease models and understand how dysfunctions of ion channels contribute to human diseases, and to develop novel pharmacogenomic approaches targeting ion channels for disease intervention.
PHRM 847000 Principle of Pharmacogenomics (offered every Spring), course co-coordinator
PHRM 845000 Integrated Pharmacotherapeutics III
Service & Recognition
Membership & Awards:
F1000Prime faculty member
Ad hoc journal reviewer:
Nature Communications; Sciences Advances; Brain; Journal of Biological Chemistry; Molecular Pain; Journal of Neurophysiology; Antioxidants & Redox Signaling; Neural Plasticity; Plos ONE; Neuroscience Letters; Journal of Pharmacological and Toxicological Methods; Diabetologia; Acta Pharmacologica Sinica
Ad hoc grant reviewer:
NIH CNNT study section; CTSI pilot grant review Committee; Indiana Spinal Cord and Brain Injury Research Grant Review Committee; European Union Structural Funds-TEAM
Invited talks at:
MRC Laboratory of Molecular Biology, UK; IU/PU Joint Symposium on Spinal Cord & Brain Injury Research, IN USA; Duke Kunshan Translational Pain Research Symposium, China; National Rare Disease Reference Center of France, France; Peking University Health Science Center, China; Institute for Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; Shanghai JiaoTong University affiliated Renji Hospital, Anesthesiology division; Peking Union Medical College; Capital Medical University; Shanghai Jiaotong University, School of Medicine; Fudan University, School of Medicine; Zhejiang University, School of Medicine